Stability Study of Syrup Vs Tablet Formulation of an Anti-Viral Drug Using UV Spectrophotometer

Abstract

Stability testing is a fundamental requirement within pharmaceutical development ensure indicating that drug products maintain their safety, efficacy, and quality throughout their shelf life (9).

The evaluation of stability involves monitoring physical, chemical, and microbiological characteristics as per controlled environmental conditions since as temperature, humidity, light-induced exposure (9)

UV-visible spectrophotometry is generally employed in stability studies caused by its simplicity, expedited analysis, cost-effectives, suitability for routine quality control applications (7, 18).

Tablet and syrup dosage forms differ significantly in their composition, physical nature, and degradation behavior, so that influences analytical approaches used for stability assessment (15, 16).Solid dosage is the forms like tablets generally exhibit greater stability compared to liquid formulations due to they lack free water which promotes hydrolysis (15).Syrup formulation, being aqueous system, occur more susceptible to hydrolytic degradation, oxidation, microbial contamination (14, 15).

Numerous validated UV spectrophotometric methods have been developed for stability evaluation of both solid and liquid drug formulation forms within accordance with ICH guidelines (1, 8).

This review acutely compares stability studies of syrup and tablet formulations with the help of UV-visible spectrophotometry, highlighting analytical challenges, forced degradation strategies, validation requirements, and regulatory considerations (8, 9).