BIOACTIVE PHYTOCONSTITUENTS FOR HAIR GROWTH: SIGNALLING PATHWAYS AND EMERGING DELIVERY SYSTEM

Abstract

Alopecia, commonly known as hair loss, is a multifactorial dermatological condition that affects both men and women globally. It poses aesthetic, psychological, and emotional challenges. Current treatments such as minoxidil and finasteride offer efficacy but are often associated with undesirable side effects. Consequently, the search for alternative therapies has led to increased interest in plant-derived bioactive compounds. This review provides a comprehensive overview of herbal and phytochemical agents that promote hair growth, their mechanisms of action, and their potential integration into clinical practice. Eighteen medicinal plants traditionally used for hair restoration are discussed, with emphasis on their pharmacological mechanisms, key phytoconstituents, and experimental or clinical evidence. The review also explores future trends, including the role of nanotechnology, stem cell therapy, and gene modulation in alopecia management.