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Abstract
Cissus rotundifolia* Lam. (Vitaceae) is a medicinal and edible plant traditionally used in Africa and the Arabian Peninsula for the treatment of diabetes, gastrointestinal disorders, inflammation, infections, and nutritional deficiencies. The present study aimed to investigate the phytochemical composition, nutritional value, functional properties, and ethnomedicinal relevance of *C. rotundifolia*, with special emphasis on flavonoids, vitamins, minerals, and bioactive compounds. Plant materials were collected from mountainous regions of Yemen and subjected to proximate analysis, mineral profiling, vitamin estimation, organic acid analysis, and functional property evaluation using standard analytical methods. Flavonoid compounds were identified and quantified by HPLC, supported by UV, IR, and NMR spectroscopic techniques. DNA fingerprinting was also performed to support molecular identification and genetic characterization of the species. The results revealed that *C. rotundifolia* leaves are rich in proteins, crude fiber, essential minerals, vitamins C and E, and bioactive flavonoids, indicating strong antioxidant, anti-inflammatory, and antimicrobial potential. Functional property analysis demonstrated good water and oil absorption capacities, solubility, and foaming ability, supporting its suitability for food and pharmaceutical applications. The findings scientifically validate the traditional uses of *C. rotundifolia* and highlight its potential as a valuable nutraceutical and medicinal resource, providing a foundation for future pharmacological and industrial studies.