Articles

  1. Hyperbilirubinemia during Atazanavir treatment in HIV/AIDS patients taking second line ART drugs Download Article

    Savithri Desai, Harish.G.Bagewadi, Harinika G
    • Type: Research Article
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    • Pages (01-06)
    • No of Downloads: 27

    Abstract

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    Background

    Hyperbilirubinemia is frequently observed in HIV (Human Immunodeficiency Virus) patients treated with Atazanavir containing antiretroviral regimen in the dose of 300 mg once daily. However, little is known about the incidence of Atazanavir-associated hyperbilirubinemia in Asian population. Hyperbilirubinemia is defined as an excess of bilirubin in blood either conjugated or unconjugated.

    Aim

    To estimate the incidence of Atazanavir associated hyperbilirubinemia in HIV patients receiving second line antiretroviral regimen advocated by National AIDS Control Organisation (NACO) by measuring serum bilirubin levels.

    Materials and Methods

    The study was done in 100 HIV-infected patients attending ART Plus centre at a tertiary care centre receiving Atazanavir regimen for a period of 12 months. The bilirubin levels in blood were estimated by MALOY & EVELYN METHOD.

    Results

    The incidence of grade I hyperbilirubinemia was 26%, grade II was 24%, grade III was 48% & grade IV 2%. The Study data suggested that Atazanavir-associated hyperbilirubinemia is common and self limiting.

    Conclusion

    It was observed that most of the HIV/AIDS patients receiving Atazanavir containing ART regimens developed hyperbilirubinemia, so these patients should be regularly monitored for Atazanavir induced hyperbilirubinemia.

  2. Study on the prevalence of gestational diabetes mellitus at a tertiary care hospital Download Article

    Chitra B, Shreedarshan M, Tharayil Nishi Nainan and Vishnu N
    • Type: Research Article
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    • Pages (07-11)
    • No of Downloads: 17

    Abstract

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    The prevalence of diabetes is increasing globally. Women with Gestational Diabetes Mellitus are an ideal group for the primary prevention of diabetes as they are at increased risk of future diabetes, predominantly type 2 diabetes, as are their children. A prospective observational study was carried out in gynaecology department over a period of 6 months enrolling 150 patients. The study was carried out to identify the prevalence of GDM, to assess the prescribing pattern of anti-diabetic drugs in GDM, to identify the risk factors involved, to assess the patient’s level of knowledge about diabetes and to provide patient counselling. 106 patients were diagnosed with GDM. Most commonly prescribed anti-diabetic drugs were metformin followed by insulin. The risk factors identified were age above 30 years, obesity, family history and prediabetes. The occurrence of maternal and neonatal complications in the GDM patients were observed and most frequent complication found was caesarean in 49 cases.  The assessment of distribution of patients based on gestation period revealed that patients at gestational age of 24-26 weeks of pregnancy were more frequently diagnosed with GDM. A standard questionnaire was used to assess the level of knowledge about diabetes in GDM patients. Based on the level of knowledge, the patients were educated regarding the disease and lifestyle modification with the help of patient information leaflet. . The severity of drug interactions were evaluated and found that 13 prescriptions had major interactions, followed by 36 moderate interactions and 12 minor interactions. The present study points out the role of a clinical pharmacist in improving the patient care and overall quality of life in GDM patients.